Amy Jo Johnson is a singer-songwriter and has released three albums: The Trans-American Treatment (2001), Imperfect (2005), and Never Broken (2013). She has performed in the Los Angeles area with The Amy Jo Johnson Band. In December 2007, she contributed guest vocals to Koishii & Hush's cover of The Cars track "Since You're Gone", which was released as a single.
Some of Johnson's music has been featured on television shows. Johnson's character in Felicity was originally described as a dancer, but with Johnson's input, the producers rewrote the character as a singer and guitarist. As a result, Johnson was able to perform her own song, "Puddle of Grace," on the show. In Flashpoint, her songs "Dancing In-Between" and "Goodbye" were featured.
In 2013, she had performed the song "God" from her movie Bent. In 2014, her song "Lines" had featured in her movie Lines. In 2017, her song "Cracker Jacks" is the theme song from the movie The Space Between.